Trigeminal neuralgia is a craniofacial pain condition characterized by severe paroxysm pain, often described as lancinating or electrical, lasting seconds to minutes in the trigeminal distribution. Dandy first proposed that neurovascular compression of the trigeminal nerve was a potential cause of trigeminal neuralgia [1]. Compression of the trigeminal nerve at the root entry zone by a blood vessel is clearly the most common “anatomical” association in patients with trigeminal neuralgia. Vascular compression may lead to hyperexcitability of injured or demyelinated axons [2], which may result in ectopic high-frequency discharges large enough to trigger spreading depolarization in ganglionic nociceptive neurons [3]. Jannetta established microvascular decompression (MVD), i.e., separating the conflicting vessel from the injured nerve, as one of the most important surgical treatments of trigeminal neuralgia [4].