Vegetable crops are sensitive to different biotic and abiotic stresses like drought, salt, heat, chilling, flood, pests and diseases, etc., which severely affect the quality and yield of vegetables. Being the major source of nutrition in diet, the magnitude of the losses caused by diseases in vegetable crops is a serious threat to nutritional security. This necessitates the focused breeding activities for the development of stress-tolerant vegetable cultivars. Apart from molecular breeding, the recently developed genome editing technique using CRISPR/Cas9 is the most potential approach for achieving stress tolerance in plants. Among the different genome editing tools available so far, CRISPR/Cas9 is the most efficient and simple tool. This has resulted in the identification of more Cas variants and the development of tools for various applications like gene knockout, RNA editing, base editing, gene activation, chromosome engineering, nucleic acid detection, chromatin imaging, etc. One of the most fascinating applications is base editing, where one can irreversibly convert one nucleotide base to another at desired location in the genome. After initial demonstration of CRISPR/Cas9 tool for developing plants resistant against viruses, it has been further utilized in different vegetable crops primarily by targeting the susceptibility genes in plants required for infection and survival of the pathogens. One of the best examples is the knockout of the MLO gene causing downy mildew resistance. Resistance against RNA viruses has been developed in cucumber by targeting the eIF4E gene. Most of the work has been carried out in tomatoes, where knockout of genes like MAPK3 and CCD8/MAX1 resulted in resistance against Botrytis cinerea and Phelipanche aegytiaca, respectively. In tomato, DMR6 mutant plants can be obtained using CRISPR/Cas9 to develop plants resistant to fungal and bacterial diseases. Genome editing has also proven worthy for developing abiotic stress tolerance by targeting transcription factors or negative regulators of stress responsive pathways. Drought-tolerant gene-edited tomatoes have been developed by editing NPR1, MAPK3, LBD40 and ARF4 genes. Similarly, salt tolerance trait has been developed in potatoes by targeting Coilin and HyPRP1 genes. With CRISPR/Cas tool in the armor, the development of stress-tolerant vegetable cultivars is only limited by the availability of susceptible or negative regulator genes and regeneration and transformation protocols.