Seismic vulnerability and its assessment are an imperative study and to this end, the present paper investigates the seismic effects of Unreinforced Masonry (URM) infill walls on RC frame buildings, highlighted by the 2001 Bhuj earthquake’s findings regarding their ability to withstand lateral forces. Despite their common use for partitioning due to enhanced functionality, accessibility, and affordability, URM infill walls are often designed as non-structural elements, with their potential to augment lateral strength and stiffness frequently overlooked in the design phase. In the present study, 4-Storey, 8-Storey, and 12-Storey RC frame buildings were designed as per the latest Indian seismic provisions. Nonlinear static pushover analysis is implemented on the selected bare, open ground Storey and fully masonry infill walls configuration. A nonlinear Single-strut model is adopted for the masonry infill walls. Evaluation of the Response reduction factor and its primary parameters are estimated as per the ATC-19. URM Infill walls significantly affect the ductility and strength of the structures, with variations observed across the different building heights. The results highlight the substantial impact of masonry infill walls on the seismic performance of RC frames. URM Infill walls resulted in a significant decrease in ductility, reaching up to 53 per cent. On the other hand, strength ratios experienced modest increases, reaching up to 10 per cent. This study provides valuable insights into the seismic behavior of RC frame buildings with URM infill walls, highlighting the importance of rethinking design considerations to maximize the benefits of infill walls in improving structural performance during earthquakes, in accordance with Indian seismic standards.