Present paper deals with the cost effective design of reinforced concrete building frame employing unified particle swarm optimization (UPSO). A building frame with G + 8 stories have been adopted to demonstrate the effectiveness of the present algorithm. Effect of seismic loads and wind load have been considered as per Indian Standard (IS) 1893 (Part-I) and IS 875 (Part-III) respectively. Analysis of the frames has been carried out in STAAD Pro software. The design loads for all the beams and columns obtained from STAAD Pro have been given as input of the optimization algorithm. Next, cost optimization of all beams and columns have been carried out in MATLAB environment using UPSO, considering the safety and serviceability criteria mentioned in IS 456. Cost of formwork, concrete and reinforcement have been considered to calculate the total cost. Reinforcement of beams and columns has been calculated with consideration for curtailment and feasibility of laying the reinforcement bars during actual construction. The numerical analysis ensures the accuracy of the developed algorithm in providing the cost optimized design of RC building frames considering safety, serviceability and constructional feasibilities. Thus, the present algorithm is capable of giving a cost effective design of RC building frame, which can be adopted directly in construction site without making any changes.