A structure can be categorized as irregular if it contains uneven distributions of mass, stiffness and strength or due to irregular geometry. Most structures contain irregularities due to functional and aesthetic reasons. One of the significant reasons for a structure’s collapse from past earthquakes is the irregular configuration of the building, either in plan or elevation, as the performance of a building during a seismic occasion primarily depends on its configuration. Thus, irregular structures situated in highly seismic zones are a matter of concern. The choice of type, location and degree of irregularity is crucial in the design of structures. IS Code 1893:2016 (Part 1) recommends that all efforts should be made to remove irregularities by revising structural configuration and architectural planning. However, in structures, the concept of “perfect regularity” is just an idealization as real structures contain irregularities necessitated due to various needs and demands and also constitute a large portion of modern urban infrastructure. The main aim of the present work is to incorporate irregularities in a structure without compromising its performance. A G+10 storey regular building Reinforced Concrete frame is modified by incorporating single as well as combined irregularities involving re-entrant corners, floor slabs having excessive openings or cut-outs, mass, and vertical geometric irregularities. All the models are subjected to earthquake loading, and the responses are computed using CSI ETABS software. The objective will be accomplished by comparing the responses of the various models by a method of seismic analysis namely Response Spectrum Analysis.