This is the last chapter of the book, and it highlights the innovations of blended learning presented by authors of various chapters on case studies. First, this chapter presents lessons emerging from different case studies presented in the book to help practitioners, researchers, instructional designers, institutions, and policymakers integrate blended learning into higher education for twenty-first century learners. Second, the chapter lists various best practices that can be used for designing, developing, and implementing blended teaching–learning effectively in real and authentic contexts/situations. This chapter also serves as a reminder that blended learning is an approach of teaching–learning with much potential, and that all the stakeholders must play their roles carefully and effectively to make it an integral part of higher education systems with the prime goal of improving the quality of student learning.