COVID-19 associated mitigation measures imposed across countries to curb the spread of the disease appear to have negatively impacted the well-being of people in diverse ways. While much has been documented on issues of domestic abuse, anxiety, and mental health, only little or no attention has been paid to issues of exacerbated gender inequalities and attenuated sexual well-being, particularly on sexual desire and/or pleasure of middle-class married women in heterosexual relations. Heterosexual married women have been significantly impacted by gender inequalities, which contribute to and have exacerbated the sexual pleasure gap between heterosexual married men and women. Moreover, the social consequences of the COVID-19 outbreak have been uneven, with several deleterious effects on heterosexual married women’s sexual well-being. Based on ethnographic data collected during, before, and after the lockdown, this research sought to highlight how the COVID-19 pandemic contributed to social, sexual and emotional inequalities among middle-class heterosexual married women in Tema, Ghana. Our data shows that the COVID-19 pandemic not only affected the health of people at risk but also significantly impacted the sexual well-being of heterosexual married women. Although COVID-19 presented unplanned and unexpected situations for heterosexual spouses and families, it also presented novel ways of expressing love and care and seeking sexual pleasure and/or desire. Using the notion of sexual well-being, we show that heterosexual pleasure, companionship, and intimacy were important to these heterosexual married women. Therefore, they strived, negotiated, and navigated through these barriers to attain their sexual well-being.