The production of halal pharmaceuticals in Muslim countries is a growing industry with high market demand. Muslim consumer spending on pharmaceuticals was USD108 billion in 2022 and is forecast to reach USD142 billion in 2027. Due to the growing demand for halal pharmaceuticals, business leaders have begun to respond to the call for halal integrity in medicines and related products in which all ingredients should be permissible to use and consume and be alcohol-free. This chapter examines the use of a traceability system to ensure the halal integrity of pharmaceuticals. A traceability system enables the identification of product ingredients’ halal status along the production chain and can also act as a communication tool to ensure that information related to halal products is available along the supply chain and eventually to consumers. The chapter gives an overview of the development of the use of traceability systems in the pharmaceutical supply chain, including the use of state-of-the-art technology, through case studies of Malaysia, Japan and Brunei Darussalam.