The growing demand to meet the needs of the population has generated various environmental impacts that are sometimes irreversible, specifically in the area of water, and to minimize impacts, conventional treatments have been implemented, which are divided into physical, chemical, and biological; however, these are not designed for the removal of emerging compounds (EC) such as: pesticides, flame retardants, microplastics, surfactants, analgesics, and antibiotics, among others. Therefore, biohybrid treatments have currently been proposed, which consist of the combination of a conventional process with a biological treatment, coupled with high efficiency, and value-added bioproducts can also be obtained. Some examples of biohybrid treatments, but not limited to them, are: (i) membrane biological processes (MBR), (ii) biological treatment with a moving bed reactor, (iii) disinfection processes with biological treatment, and (iv) advanced oxidation processes (AOPs) with physicochemical and biological treatments. These biohybrid treatments offer new opportunities to revolutionize environmental remediation, up to biomedical applications directly impacting the economy. Given this concern, microalgae turns out to be an excellent renewable raw material for the refining of different types of wastewater combined with conventional treatment. In addition, they are commonly found in various ecosystems, and value-added products are obtained that can be used directly or as a precursor of bioenergetics, considering it an attractive process for the circular economy. Therefore, this chapter addresses the issue of wastewater treatment with AOPs to subsequently refine them with microalgae as an excellent alternative for water reuse, generation of value-added bioproducts, and production of bioenergetics, to be incorporated into the bioeconomy cycle and contribute to the fulfillment of the objectives of the 2030 agenda.