Crystal Structure Control Technology for Organic and Biomaterials Using Light

This chapter explores the advanced developments in laser-induced crystal nucleation technology. The initial phase of this technology enabled the synthesis of previously inaccessible substances, while the current phase, addresses the separation of similar substances via laser irradiation, thereby facilitating precise control over crystal polymorphism. Considerable advancements have been achieved in the metastable crystallization of aspirin, a compound that has historically posed significant challenges for polymorphism control. Nevertheless, numerous materials continue to exhibit complexities in crystallization and polymorphism management. To broaden the applicability of this technology to a wider array of substances, it is imperative to conduct a more thorough investigation of the phenomena induced by laser irradiation. Future endeavors will focus on leveraging light to actively manipulate crystal phase transitions, thereby enabling precise molecular-level interventions. This approach aspires to develop materials that replicate the intricate polymorphism control mechanisms inherent in biological systems.