Material fabrication is the crucial parameter for their different kinds of scientific and technological uses. Therefore, the knowledge of the synthetic approaches of any kind of materials is helpful to obtain desired properties for a specific technological purpose. More precisely, the different synthetic approaches of the two-dimensional nanomaterials are largely affect their potential properties. Therefore, to a systematic study of the TMDs, this chapter work devoted to various synthetic approaches such as top-down; including liquid exfoliation, mechanical exfoliation, electrochemical exfoliation, and bottom-up; including growth mechanism, metal chalcogenisation via sulfurization/selenization, thermolysis from thiosalts, transition metal - chalcogen precursors via vapor pressure reaction, TMDs alloys growth, epitaxial growth of TMDs, atomic layer deposition (ALD) and layer transfer. Descriptions of these synthetic approaches would be helpful to employ accordingly for the targeted desired utility of the TMDs materials.