This comprehensive clinical study investigates the efficacy of the Unit for the Treatment of Substance Use Disorders and Alcoholism's (UTITA) rehabilitation program, which incorporates the Minnesota Model and the Multidimensional Model for addressing substance dependence in both military and civilian populations. Utilizing a clinical follow-up period spanning from 2013 to 2023, involving 983 participants, the research examines the complex interaction of psychosocial, contextual, and lifestyle factors influencing treatment outcomes. The study´s key findings highlight the significance of regular engagement in mutual support meetings, engagement in relapse prevention sessions, and the presence of a social support network in maintaining abstinence. The observed variation in abstinence rates between military and civilian populations underscores the impact of contextual influences on addiction treatment outcomes. Lifestyle factors, encompassing stability in family and professional spheres, adherence to a balanced diet, and participation in leisure activities, emerge as critical determinants of long-term sobriety. The study's robust methodology and detailed analysis affirm the effectiveness of UTITA's program, providing actionable insights for personalized interventions and emphasizing the need for holistic approaches in addiction treatment. In conclusion, this research contributes to the evolving knowledge in addiction science, advocating for tailored, community-centered, and family-focused strategies to enhance treatment efficacy.