With the rapid development of artificial intelligence technology, the problems existing in the curriculum system, teaching content and teaching methods of traditional innovation and entrepreneurship education in colleges and universities have become increasingly prominent. However, artificial intelligence technology can help colleges and universities better grasp the learning needs of students, improve teaching methods and enhance the quality of innovation and entrepreneurship education. Therefore, colleges and universities should deeply integrate artificial intelligence technology with innovation and entrepreneurship education, build an innovation and entrepreneurship education curriculum system of “one core, one platform and two supports” for students’ personalized learning needs, explore the innovation and entrepreneurship teaching method of “promoting teaching by competition, promoting learning by competition, and promoting innovation by competition”, and build a new model of double innovation education of “broad training, cross-training and integrated training”.