With the rapid development of the industrial sector, the amount of hazardous waste generated is increasing, and hazardous waste treatment has become an important element of ecological environmental protection. At present, China's hazardous waste treatment faces problems such as single treatment technology, backward environmental monitoring system and lack of information sharing platform for hazardous waste treatment. Therefore, this paper is based on the Internet of Things GIS technology to build a hazardous waste information management system, in view of the above problems, the design of hazardous waste generation management module, collection and storage management module, transportation and transfer management module, disposal and utilization management module, as well as laws and regulations, hazardous waste information management module. This system effectively improves the traditional waste management mechanism, intelligently monitors the whole process of hazardous waste generation, collection, storage, transfer, utilization and disposal, and builds an information sharing platform for hazardous waste treatment, so as to realize the efficient treatment and management of hazardous waste.