Scholarlink

The functions of bones depend on the proteins involved in it and in ossification. In addition to collagenous and non-collagenous proteins, there are other proteins that play a significant role in bone function. The proteins can be categorized into two groups: plasmatic proteins and cytoskeleton proteins. Plasmatic proteins include transferrin, immunoglobulin, albumin, α2HS, and phospholipid transfer protein. Tensin, vinculin, talin, and paxillin are proteins that make up the cytoskeleton. Transferrin plays a vital role in the process of attaching to and carrying iron throughout living organisms. Antibodies, also known as immunoglobulins, recognize antigens present on the surfaces of foreign entities such as viruses and bacteria. They then trigger mechanisms like phagocytosis and cell lysis to destroy these infectious particles and cells. Albumin, the predominant protein in plasma, is an essential constituent of the fluid located outside of blood arteries, referred to as extravascular tissue fluid. Albumin and plasma α2HS glycoprotein exhibit elevated concentrations within the bone matrix, while immunoglobulin G is mostly associated with the blood capillaries in the bone. Phospholipid transfer proteins (PLTPs) are proteins present in the plasma that can transfer phospholipids between lipoproteins and liposomes. Tensin has a crucial role in linking the actin cytoskeleton, extracellular matrix (ECM), and signal transduction. Vinculin regulates adhesion via recruiting actin remodeling proteins, facilitating actin polymerization, and directly binding to actin, despite its limited enzymatic activity. Paxillin is a versatile protein that acts as an adaptor in focal adhesions, playing a crucial role in cell migration and movement. Talin is an essential protein that connects the cytoplasmic parts of integrin β subunits to actin filaments. Understanding the activity of these cells can have a significant impact on the development of materials used in bone tissue engineering. This chapter offers extensive details on the composition and functions of these proteins.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bone ECM Proteins—Part II

  • 章节

  • 发表日期：

    2025年

查看全文
  • Reza Gholami,
  • Seyed Morteza Naghib

摘要

The functions of bones depend on the proteins involved in it and in ossification. In addition to collagenous and non-collagenous proteins, there are other proteins that play a significant role in bone function. The proteins can be categorized into two groups: plasmatic proteins and cytoskeleton proteins. Plasmatic proteins include transferrin, immunoglobulin, albumin, α2HS, and phospholipid transfer protein. Tensin, vinculin, talin, and paxillin are proteins that make up the cytoskeleton. Transferrin plays a vital role in the process of attaching to and carrying iron throughout living organisms. Antibodies, also known as immunoglobulins, recognize antigens present on the surfaces of foreign entities such as viruses and bacteria. They then trigger mechanisms like phagocytosis and cell lysis to destroy these infectious particles and cells. Albumin, the predominant protein in plasma, is an essential constituent of the fluid located outside of blood arteries, referred to as extravascular tissue fluid. Albumin and plasma α2HS glycoprotein exhibit elevated concentrations within the bone matrix, while immunoglobulin G is mostly associated with the blood capillaries in the bone. Phospholipid transfer proteins (PLTPs) are proteins present in the plasma that can transfer phospholipids between lipoproteins and liposomes. Tensin has a crucial role in linking the actin cytoskeleton, extracellular matrix (ECM), and signal transduction. Vinculin regulates adhesion via recruiting actin remodeling proteins, facilitating actin polymerization, and directly binding to actin, despite its limited enzymatic activity. Paxillin is a versatile protein that acts as an adaptor in focal adhesions, playing a crucial role in cell migration and movement. Talin is an essential protein that connects the cytoplasmic parts of integrin β subunits to actin filaments. Understanding the activity of these cells can have a significant impact on the development of materials used in bone tissue engineering. This chapter offers extensive details on the composition and functions of these proteins.