Mentha arvensis (Japanese mint) is cultivated for production of essential oil. This oil contains menthol (74%) as bioactive compound for using as nutraceutical and pharmaceutical ingredient. The mentha essential oil (0.97%) was obtained from fresh biomass through hydro-distillation for 4 to 5 h, and the rest after distilled biomass (99%) was generated as waste. India produces more than 42,000 Ton of mint oil with World share above 70%. In the process of distillation, more than 8.0 million tons per annum of mentha spent biomass generated, and this hydro-treated biomass can be considered for value addition. In the present study, a greener and economical solvent imidazole-p-toluene sulfonic acid (1 M) was used for isolation of lignin at optimized reaction condition. Subsequently, IM (0.2 M)-20%NH3 was used for isolation hemicellulose from de-lignified biomass. The hemicellulose and lignin were recovered from the respective solution as precipitate, and remaining undissolved leftover solid residue was cellulose. The cellulose (37%), hemicellulose (28%), and lignin (14.3%) were isolated from 1 kg de-wax mentha biomass. The purity of this isolated cellulose is more than 97%. A greener solvent system was developed using eutectic mixture, viz., choline chloride (Ch), citric acid (Ct), and ionic liquid such as 1-ethyl-3-methyl-imidazolium chloride (EMIMCl) for dissolution of cellulose at 120 °C for 2 h. This cellulosic solution was treated with equal ratio of zeolite-phosphomolybdic acid for the production of hydroxymethylfurfural (HMF). The isolated yield of HMF was 40.1% with more than 96% analytically pure for application in number of commodity products.