Cosmeceuticals: Merging in Cosmetics and Pharmaceuticals

Making visible improvement in wrinkling and hyperpigmentation in patients is currently possible with topical cosmeceutical agents, although treatment response depends on several variables such as severity of symptoms, skin type or ethnicity, active ingredient, formulation, concentration, and patient compliance. A wide variety of active ingredients are now being used in dermatology, including peptides, growth factors, cytokines, and vitamins, and these have expanded the cosmeceutical industry. The key concerns in periorbital aging include periorbital wrinkles, dark circles, and tear trough deformities, all of which contribute to an aged and fatigued appearance. The tear trough is an anatomical or structural issue and typically requires surgical or minimally invasive interventions. However, fine periorbital wrinkles and periorbital dark circles can be improved with non-procedural and topical approaches. This chapter has provided a comprehensive overview of the most important cosmeceutical agents used for periorbital rejuvenation, including: Together, these ingredients offer a noninvasive, multi-mechanistic approach to managing periorbital concerns and addressing pigmentation, inflammation, collagen loss, dehydration, and oxidative stress. When selected appropriately and used consistently, these agents can produce visible improvement in texture, tone, hydration, and overall appearance of the delicate eye area—particularly when integrated into a broader dermatologic or aesthetic treatment strategy.