Diabetic neuropathy is frequent, affecting 50% of individuals suffering from Type 1 or Type 2 DM. It is a major cause regarding diabetes-related hospitalizations and nontraumatic amputations. Currently, managing diabetes involves maintaining normal blood sugar levels and treating symptoms. Despite numerous studies on persistent pain linked with diabetic neuropathy, little progress has been made. The present book chapter covers the classification of diabetic neuropathy, its molecular causes, and therapy possibilities, focusing on antioxidants. Antioxidants combat oxidative damage to improve nerve function in diabetes through several methods and areas of action. Understanding how hyperglycemia causes free radical damage have being crucial thereafter might possibly accord to diabetic neuropathy. New targets for disease-modifying medicines could be identified. There is no remedy for DN, thus determent is critical. Although rigid sugar management can reduce course of diabetic neuropathy, there is still a need for more effective therapies. As a result, more patients seek dietary supplements with neuroprotective characteristics.