Diabetic neuropathy (DN) is a severe diabetic consequence characterised by nerve loss that causes sensory, motor, and autonomic impairment. Since oxidative stress is commonly shown to be a significant contributing element to the cause of DN, antioxidant therapy may be a viable therapeutic option. This chapter reviews clinical studies that evaluated the effectiveness of several antioxidants, including vitamin E, coenzyme Q10, and alpha-lipoic acid, in the treatment of DN. The trials show that antioxidant treatment has the capability to lower oxidative stress indicators, enhance nerve function, and ameliorate symptoms of neuropathy. In multiple randomised controlled studies, alpha-lipoic acid was found to dramatically enhance neuropathic pain and nerve conduction velocity. Vitamin E has shown neuroprotective properties, while its therapeutic advantages are less consistent. Coenzyme Q10 and N-acetylcysteine have also showed potential in smaller studies, although additional research is needed in bigger trials. While the results of these trials are promising, the long-term effectiveness and appropriate dose of antioxidant treatment in DN management are currently being investigated. In general, when combined with a more comprehensive treatment plan, antioxidant therapy is a potential adjunctive treatment for diabetic neuropathy that may improve patient outcomes.