This research investigates the tribological properties, specifically friction and wear, of polytetrafluoroethylene (PTFE) coatings applied to stainless-steel discs through two distinct methods: the two methods are Ball-on-Disc (BOD) and Ball-on-Plate (BOP). In the BOD setup, the stainless-steel (SS) ball moves on the PTFE-coated disc at 1, 10 and 50 cm/sec with a 5 N load for 10 min. On the other hand, the BOP experiment involves the same SS ball reciprocating between two ends over a distance of 20 mm while employing the same load and speed characteristic of the BOD experiment. The level of increase of the coefficient of friction (COF) in these methods is high initially and gradually stabilizes over time. As the speed rises in the BOD tests, the COF increases because of the increased contact area due to the smoothening of the surface, and more wear takes place at higher speeds. However, in the BOP tests, while the coefficient of friction increases with speed, it decreases when the speed is increased to 50 cm/sec. This is brought about by third bodies where the wear debris is entrapped between the SS ball and the deposit PTFE coating, as well as PTFE softening due to temperature increase leading to increased wear but decreased friction. Finally, despite similar values of COF obtained by both methods, quite different wear profiles are seen. For instance, the BOP method shows more apparent signs of wear than the BOD method. From these, we can infer that it highly depends on the kind of application, and thus, the most suitable testing method should be selected.