Nematicides like fluensulfone, fluopyram, and fluazaindolizine are novel, less toxic nematicides for managing plant nematodes. These nematicides, registered since 2014, offer lower toxicity and environmental impact compared to older options. Biological options, like Arino (powered by RinoTec™ Technology), offer sustainable, low-toxicity alternatives. The evidence leans toward ongoing development, but specific 2025 innovations are not widely documented yet. This chapter provides a comprehensive overview of novel, less toxic nematicides for managing plant-parasitic nematodes. It includes detailed characteristics, efficacy, and market trends, ensuring a thorough understanding for agricultural professionals and researchers.