Research on ventilators is increasing along with the increasing human need for mechanical breathing aids. A mechanical ventilator is a device that can provide respiratory support to maintain life in patients who require long-term ventilation assistance due to respiratory disorders or failure. The development of pressure control is vital to avoid barotrauma or hyperventilation, and the development of oxygen control is essential to prevent hypoxia or hyperoxia. This study uses a microcontroller with better performance than previous studies and complements the needs of health workers in providing medical interventions to patients. This research aims to develop a pressure control and oxygen control method using STM32F407VGT6 as a microcontroller with a fuzzy logic method as a closed-loop control system. The results of this development showed that the accuracy of the inspiratory pressure parameter in pressure control was tested with a VT analyzer, and the accuracy of the output results of the tool was tested at 91.98% to 98.54%. In comparison, oxygen control had an accuracy of 89.9% to 99.6%. These results of the performance test comply to the BPAFK standards, Ministry of Health Republic of Indonesia for maximum error in accuracy.