This chapter presents a CBT-based framework for managing substance use among people with psychosis. It defines treatment goals and describes assessment using TAPS, general physical examination, and urine testing to identify substance types, severity, and medical complications. The chapter then outlines how to choose appropriate techniques based on patient profile and substance, with specific sections on contingency management, habit reversal, and the use of Exposure and Response Prevention approach to work with substance-related cues and cravings. The overall focus is on reducing use, minimizing relapse risk, and stabilizing psychotic symptoms as part of an integrated treatment plan.