Depressive disorders are a leading cause of disability worldwide, contributing substantially to functional impairment, reduced quality of life, and socioeconomic burden across populations. Although effective pharmacological and psychological treatments are available, disability care for depressive disorders remains inadequately addressed due to fragmented mental health systems and limited coordination across services. Such fragmentation often results in discontinuity of care, delayed rehabilitation, and poor long-term functional recovery. This chapter examines the importance of systems-based integration in addressing disability associated with depressive disorders, emphasizing coordinated healthcare delivery across clinical, rehabilitative, community, and social support domains. Integrated care models, including primary–secondary–tertiary healthcare linkages, collaborative care, and stepped-care frameworks, are discussed as effective strategies for improving access, continuity, and outcomes in depressive disability care. The role of multidisciplinary mental health teams in promoting interprofessional collaboration and shared decision-making is also highlighted. The chapter further explores the contribution of community-based and institutional support systems, including rehabilitation services, non-governmental organizations, and social welfare agencies, in facilitating recovery and social reintegration. Emerging digital and technological interventions, such as telepsychiatry and electronic health records, are examined for their potential to enhance care continuity and system integration. Barriers to effective integration, including structural constraints, workforce shortages, stigma, and policy limitations, are critically analyzed. Finally, strategies for strengthening integrated disability care systems through policy reform, capacity building, and service redesign are proposed, with lessons drawn from national and international models relevant to low- and middle-income settings.