With the extension of the development period, a certain low-permeability oilfield has now entered the high water cut development stage, with the comprehensive water cut of the oilfield reaching 84.2%. Based on historical analysis, in 2023, wells with a comprehensive water cut greater than 60% in this low-permeability oilfield have accounted for 82.1% of the total number of wells. The remaining oil is distributed in a scattered manner, the decline rate of the oilfield's output has increased, and the difficulty of tapping potential has become greater. Fracturing, as the main measure for increasing production, has seen an increasing proportion of annual oil increment, accounting for 5% of the oilfield's output. To further ensure the effectiveness of fracturing measures, this paper analyzes the effects of conventional fracturing wells in the past five years, clarifies the main controlling factors of fracturing, and forms the “three highs and one low” well selection criteria of effective thickness greater than or equal to 2 m, remaining oil saturation in the main layer greater than or equal to 50%, and recovery degree less than 20%; and the “two lows and one high” layer selection criteria of target well thickness in low water cut favorable facies sand bodies, favorable facies thickness greater than or equal to 1.0 m, the number of connected directions of low and unutilized layers greater than or equal to 2, and the number of connected directions of high oil content and unwatered layers greater than or equal to 1, with the presence of favorable sand bodies with thickness around that can be communicated. This precisely identifies potential layers, providing a guarantee for the oilfield's increased and stable production.