The development of oil-water transition zones faces a series of challenges, including complex oil-water distribution, poor crude oil flow capacity, rapid increase of water cut, and low oil production rate. S block is located in a transition zone of a certain Oilfield. From 2009 to 2012, inverted nine-point well pattern with small well spacing was adopted to develop S block. Besides, the injected medium was steam rather than water for decreasing oil viscosity. However, in the late stage of steam flooding trial, due to low injection-production ratio, formation energy deficit, and high water cut, production rate of S block decreased rapidly. In order to solve the problems of insufficient water injection and significantly higher water cut of S block after steam flooding, it was decided to switch steam flooding to water flooding for this block. At the same time, through converting specific oil wells of the original inverted nine-point well pattern to injection wells, five point method well network could be achieved for improving water flooding control degree and increasing flooding directions. Based on fine reservoir description, production data, and interpretation results of profile testing, a comprehensive development adjustment strategy was further established by combining subdivision and reorganization of injection segments, injecting scheme adjustment of water wells, and specific measures for oil wells. By applying this series of adjustment measures to transitional zone S block, prominent developing effects were obtained including high sweep efficiency, sufficient formation energy and alleviated contradictions. Formation pressure had increased by 3.9 MPa, water cut had decreased by 0.7 percentage points and daily oil production rate of the block had increased by 7 tons. The comprehensive development adjustment measures proposed in this article can provide reference for the development of similar transition zones.