Disability refers to any physiological or cognitive condition that limits an individual’s ability to perform regular duties or interact with others socially. This chapter explores how the perception of disability has evolved from one of marginalization and stigma to a framework centered on rights, integrity, and moral inclusion. It examines the evolution of disability models, encompassing medical, sociological, and bioethical perspectives, and their influence on attitudes, laws, and research methodologies. The impact of historical injustices on contemporary disability ethics, including forced sterilization, institutionalization, and Nazi eugenics initiatives, is examined. Intersectionality serves as a framework that connects disability with other marginalized identities to combat systemic injustices. The UN Convention on the Rights of Persons with Disabilities (CRPD) acts as a standard for international justice and self-determination. Altogether, this chapter highlights the inevitability of intersectional, ethically upright, and rights-based strategies to ensure the representation, equity, and dignity of people with disabilities.