According to the Realist-Constructivist perspective, the global ecology of skill formation is surrounded by a nexus of generative mechanisms. Using cross-national data from Pakistan and Ghana, this chapter examines how generative mechanisms, particularly those related to economic and socio-cultural aspects, influence the skill formation of female workers across different micro-ecologies. This chapter examines variations in skills and characteristics between formal and informal workers in the two countries. The results from the logistic regression models showed significant demographic and skill divergences between Ghanaian informal and formal workers in most domains, whereas these differences were not observed among Pakistani workers. The heterogeneity observed in Ghana is attributed to the intersection of greater market opportunities for microentrepreneurship in the garment sector and less restrictive gender norms in society, compared to those in Pakistan. Instead, the variation in skill formation among Pakistani female workers is rather associated with conditions within the micro-ecology. The results of an ordered logistic model indicated that the firm’s characteristics and decisions regarding skill development, as well as supervisors’ perceptions of skills and women’s social roles, were significant factors. Taken together, these phenomena explain how generative mechanisms, which constitute the outermost layer of the framework, shape narratives within micro-ecologies and facilitate skill formation at the individual level.