The extracellular matrix (ECM) serves as a critical framework for cellular processes, providing structural support and biochemical cues that regulate cell behavior. Its complex composition, which includes proteins like collagen and elastin, along with glycosaminoglycans and proteoglycans, is tailored to the specific needs of tissues. The understanding of ECM as a dynamic entity rather than a static scaffold has transformed perspectives in cell biology, emphasizing its role in maintaining tissue integrity and facilitating communication between cells (Frantz et al. in J Cell Sci 123:4195–4200, 2010 [1]). This realization has highlighted its importance in both normal physiological processes and pathological conditions. In functioning of human body, ECM orchestrates essential cellular functions such as adhesion, migration, proliferation, and differentiation. By acting as a reservoir for growth factors and providing mechanical signals, the ECM ensures a balance between tissue homeostasis and repair. The adaptability of ECM components to varying physiological demands underscores its significance in sustaining life. These dynamics are particularly evident in developmental biology, where ECM remodeling guides organogenesis and tissue specialization.