Integrated water resources management (IWRM) techniques are essential to meet the growing demand for potable water in rapidly expanding urban areas as well as in remote locations. This includes efficient extraction, treatment, and supply of water, supported by the delivery of climate-resilient investments in water infrastructure, information, and institutions, in order to achieve the Sustainable Development Goals (SDGs), especially in developing countries. In this context, Science, Technology, and Innovation (STI) play a crucial role in diverse water management activities. In order to understand the problems of salinisation and groundwater contamination resulting from dynamic coastal environments, where poor quality water may affect the health and well-being of communities, a groundwater hydrogeochemical study was conducted in the Ada East and West Districts of the Greater Accra region of Ghana. The objective of the project was to use innovative and cost effective methods to support the country’s scientific strategies to alleviate the mounting stress on water resources, and to identify appropriate and multiple solutions to abstract, augment, and recycle water under various conditions of input water quality, nature of use, and the quantity of water required for different purposes. This paper illustrates the various features of the project and how it has complemented the water management efforts in Ghana.