This study aims to produce a highly porous stable alginate/clay -based biocomposide with a regular spherical shape as a potential candidate for bioactives molecules delivery. Alginate/clay-based microspheres, with the ability to tune their structures and porosities, are well suited to serve as carriers for sustainable drug delivery such as caffeine. The impact of formulation parameters, encompassing clay content, CaCl₂ concentration (used as the crosslinking agent), and pH, was studied to enhance porosity, mechanical strength and stability of this biocomposite. The results show that 2.5% of alginate leads to the formation of regular spherical shape of the biocomposite. In addition, the variation of clay concentration up to 7% and neutral pH increases the encapsulation efficiency of caffeine. These microspheres could achieve higher caffeine drug-loading content close to 70% leading to a controlled drug release up to 24 h under incubation at 37 C in PBS. Taken together, these novel microspheres generation open the way for their application in the biomedical field, particularly in topical applications requiring localized and efficient drug delivery systems.