Climate change is leading to higher temperatures, altered rainfall patterns, and an increase in extreme weather events like droughts, floods, and heatwaves. These changes negatively affect global agriculture, leading to lower crop yields and threatening food security. Millets are climate-resilient crops that have ability to tolerate environmental stress like heat, salinity, poor soil condition, and drought stress. They stand with very less inputs, which makes them necessary for sustainable agriculture under harsh conditions. Millets are considered to be more nutritious than the majority of main cereals, as they provide high levels of dietary fibre, essential amino acids, vitamins, storage proteins, and various health-promoting bioactive compounds. This chapter includes the effects of climate change on major and minor millets with impact of heat, waterlogging, elevated CO2, salinity, and soil changes. It also focuses on the genetic and genomic resources available for millet improvement, along with recent advances in transgenic and genomic editing methods such as CRISPR/Cas9 to increase climate resilience. The kranz anatomy of the C4 plant makes them more valuable than the C3 plant along with its nutritional benefits. Millets are rich sources of protein, calcium, and viable minerals as compared to cereals which make them nutri-cereals. Recent advancement in genomics have made millets more promising crop not only for their nutrition point but also for climatic stress tolerance which make millets a future crop.