Prior to the fabrication of the scaffold, it is very important to model it to test its physical behavior when it operates as a bioimplant. The computational modeling process focusses first on the structural design, followed by proper material selection. Subsequently, various computational modeling and simulation techniques are applied to analyze the performance of the scaffolds. We will pay more attention on the materials used in the scaffold design, as well as the most advanced scaffold fabrication techniques, such as 3D printing, electrospinning, molecular self-assembly, and hybrid methods. To finish, integrative approaches and emergencies techniques will be discussed.