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Human skeleton system, weights over 10% of total body weights, plays an important role in blood production, mineral storage, and endocrine regu-lation. Similar to many other body tissues, bones are self-repairing after injuries until bone defects reach critical level. Bone scaffold is one of the most widely used implant type for critical-size bone defect surgery. In this review, the main bone scaffold design strategies are reviewed in three perspectives: the material selections, the structure generation strategies, and the bioactive components. The effect and drawbacks of each choice or strategy will be analyzed in terms of how it would affect bone scaffolds’ performance in the inflammation, repair, or remodeling phases of bone defect recovery.

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A Review of Bone Tissue Engineering Scaffold Design Strategies

  • 会议论文

  • 发表日期：

    2026年

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  • Haonan Zhang,
  • Yanen Wang,
  • Zhisheng Liu,
  • Bo Ren,
  • Minyan Liu,
  • Xiaohu Chen,
  • Yingchao Song,
  • Yixiao Guo

摘要

Human skeleton system, weights over 10% of total body weights, plays an important role in blood production, mineral storage, and endocrine regu-lation. Similar to many other body tissues, bones are self-repairing after injuries until bone defects reach critical level. Bone scaffold is one of the most widely used implant type for critical-size bone defect surgery. In this review, the main bone scaffold design strategies are reviewed in three perspectives: the material selections, the structure generation strategies, and the bioactive components. The effect and drawbacks of each choice or strategy will be analyzed in terms of how it would affect bone scaffolds’ performance in the inflammation, repair, or remodeling phases of bone defect recovery.