Movement depends on both bone and muscle function, and the relationships between them are becoming more widely acknowledged and researched. Osteopenia, osteoporosis, and sarcopenia are important musculoskeletal conditions associated with menopause that negatively impact health, leading to poor quality of life and increased morbidity. Taken together, they come under “Osteosarcopenia”—a silent disease that slowly and gradually weakens the bone-muscle unit. Menopause is the time when attention is to be paid to detect, screen, prevent, and treat sarcopenia. This chapter deals with the current definition and methods used to diagnose and treat sarcopenia.