Menopause is marked by reduction in estrogen and progesterone levels. This influences systemic and oral health. The hormonal decline significantly affects the dental tissues, as there are estrogen receptors present in oral mucosa, salivary glands, gingiva, and jawbones. Postmenopausal women are commonly faced with xerostomia, burning mouth syndrome, altered taste perception, periodontal disease, and osteoporosis-related bone loss leading to tooth mobility or loss. These changes compromise quality of life and increase susceptibility to dental caries, mucosal discomfort, and oral infections. These conditions are exacerbated by factors such as medications, nutritional deficiencies, systemic illnesses, and lifestyle habits. Preventive and management strategies include meticulous oral hygiene, topical fluoride use, dietary modifications with adequate calcium and vitamin D, and regular dental visits for early detection of periodontal and mucosal conditions. Hormone replacement therapy although beneficial for oral symptoms, individualized risk–benefit evaluation is essential. Importantly, comprehensive care can be provided only by collaboration between dental professionals and gynecologists. By recognizing the oral implications of menopause, healthcare providers can enhance both systemic and oral health outcomes in midlife women.