This chapter examines how individual psychological mechanisms, specifically regulatory focus and uncertainty tolerance, impact opportunity recognition related to emerging technologies. Using an experiment involving 227 undergraduate business students, it explores how situational promotion and prevention focus, along with emotional responses to uncertainty, shape both the quantity and quality of opportunity recognition and generation. The findings reveal that focusing on promotion is associated with recognizing and generating higher-quality opportunities, particularly when paired with a high uncertainty tolerance. The findings provide a more profound understanding of entrepreneurial cognition by integrating motivation and emotion into the opportunity recognition process. The research has profound implications for sustainable business and social entrepreneurship, highlighting how cognitive readiness and emotional resilience enable people to identify value-creating opportunities under ambiguous, high-stakes conditions. It also emphasizes the need to cultivate such psychological traits in future entrepreneurs to address complex societal and environmental challenges.