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Intestinal mucin secreted from goblet cells forms a mucus layer, and acts as a mucosal barrier separating intestinal epithelial cells and intestinal bacteria. Recent studies on the structure and function of mucin glycans have revealed that sulfation of O-linked glycans on intestinal mucin is important for the mucosal barrier function, which maintains intestinal homeostasis and protects against inflammatory bowel diseases.

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Inflammatory Bowel Disease and Sulfated Mucin

  • 章节

  • 发表日期：

    2026年

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  • Hiroto Kawashima

摘要

Intestinal mucin secreted from goblet cells forms a mucus layer, and acts as a mucosal barrier separating intestinal epithelial cells and intestinal bacteria. Recent studies on the structure and function of mucin glycans have revealed that sulfation of O-linked glycans on intestinal mucin is important for the mucosal barrier function, which maintains intestinal homeostasis and protects against inflammatory bowel diseases.