Arthritis is characterized by inflammatory reactions in the joints, and the progression of this persistent inflammation can lead to degradation and destruction of the cartilage, contributing to the onset of osteoarthritis. Osteoarthritis is an irreversible chronic joint disease that starts with damage to the articular cartilage, causing joint pain and limiting daily activities, making it a social issue. Aging, trauma, obesity, and other mechanical stresses are thought to be involved in the onset, but the mechanisms involved in disease progression are still not fully understood, and no fundamental treatment to suppress progression has been established.