Glycolipids are complex carbohydrates bound to lipids, broadly classified into sphingoglycolipids, glyceroglycolipids, sterol glycosides, and lipopolysaccharides (Fig. 35.1). They exhibit unique biological functions and are indispensable for understanding vital life processes. Many glycolipids show considerable structural diversity in both their glycan and lipid moieties. Since they are typically present in trace amounts, there has been a strong demand for chemically synthesized standards. Among them, the chemical synthesis of sphingoglycolipids—particularly gangliosides containing sialic acid—has been actively pursued due to their biological importance. The efficient introduction of sialic acid residues into the glycan chains [1] and the development of methods for lipid attachment [2] have largely enabled the synthesis of mammalian gangliosides [3]. However, the challenge of large-scale synthesis, a long-standing issue, remains unresolved.