Glycans are molecules that play vital roles in biological systems, and their importance has been increasingly recognized in the medical and pharmaceutical fields. However, various methods for representing glycan structures as computational data have existed, including GlycoCT [1], with each database adopting different notation systems. As a result, it was not easy to obtain unified glycan structure information across databases. To address this issue, the international glycan structure repository GlyTouCan [2] was developed and is now utilized by many databases. This achievement was made possible through the development of a new glycan structure notation method, WURCS [3], capable of representing diverse glycan structures, and software enabling interconversion with existing notations (Fig. 163.1).

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Challenges and Technological Developments in Glycan Structure Information

  • Issaku Yamada

摘要

Glycans are molecules that play vital roles in biological systems, and their importance has been increasingly recognized in the medical and pharmaceutical fields. However, various methods for representing glycan structures as computational data have existed, including GlycoCT [1], with each database adopting different notation systems. As a result, it was not easy to obtain unified glycan structure information across databases. To address this issue, the international glycan structure repository GlyTouCan [2] was developed and is now utilized by many databases. This achievement was made possible through the development of a new glycan structure notation method, WURCS [3], capable of representing diverse glycan structures, and software enabling interconversion with existing notations (Fig. 163.1).