Most of the glycans present in living organisms form complex carbohydrates such as glycoproteins and glycolipids by covalently binding to proteins and lipids. Free glycans and complex carbohydrates are widely involved in the recognition system in the health status (development, cell differentiation, inflammation, signal transduction, immune regulation, etc.) and disease state (infectious, noninfectious, tumor formation, etc.) of organisms [1]. Therefore, it is important to comprehensively understand not only the molecular information that recognizes the glycan structure and its glycan but also how the glycan exists in the body and how it is distributed in the body and cells in order to understand the “function of glycans.” In recent years, multi-omics research that accumulates and analyzes a wide range of knowledge, not only glycan structures but also glycan-related gene information, glycosyltransferases, and glycan recognition molecules, has been attracting attention in the field of glycan informatics [2]. The knowledge-based TOHSA accumulates comprehensive information about all human glycans revealed in the Human Glycome Atlas Project (HGA) and promotes comprehensive glycan analysis by linking information from various fields using semantic web technology [3].

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Knowledge-Base TOHSA

  • Yukie Taylor

摘要

Most of the glycans present in living organisms form complex carbohydrates such as glycoproteins and glycolipids by covalently binding to proteins and lipids. Free glycans and complex carbohydrates are widely involved in the recognition system in the health status (development, cell differentiation, inflammation, signal transduction, immune regulation, etc.) and disease state (infectious, noninfectious, tumor formation, etc.) of organisms [1]. Therefore, it is important to comprehensively understand not only the molecular information that recognizes the glycan structure and its glycan but also how the glycan exists in the body and how it is distributed in the body and cells in order to understand the “function of glycans.” In recent years, multi-omics research that accumulates and analyzes a wide range of knowledge, not only glycan structures but also glycan-related gene information, glycosyltransferases, and glycan recognition molecules, has been attracting attention in the field of glycan informatics [2]. The knowledge-based TOHSA accumulates comprehensive information about all human glycans revealed in the Human Glycome Atlas Project (HGA) and promotes comprehensive glycan analysis by linking information from various fields using semantic web technology [3].