Glycan Antigen Remodeling of Bio-artificial Organs/Tissues

In the field of xenotransplantation, in addition to pig islet transplantation, heart and kidney transplantation from pigs has been performed clinically in recent years overseas [1]. In Japan, legal preparations are finally underway. It is uncertain whether pig organs will be treated as “bio-pharmaceuticals,” but in the United States, pigs with modified glycan genes are being produced as products. In Japan, pigs with modified genes including glycans are being developed in response to this.