The analysis of interactions (binding) between glycans and proteins, viruses, bacteria, cells, etc., is extremely important as the first step in elucidating the function of glycans at the molecular level. With the advancement of microarray technology, glycan arrays (see Fig. 10.1) that immobilize a variety of glycans on a single device can comprehensively analyze interactions [1] and have become a convenient method of analysis through quantitative analysis of affinity and combination with mass spectrometry. It is common to pre-label the binding proteins with fluorescence or visualize them with secondary antibodies, but non-label methods such as surface plasmon resonance [2] and surface-enhanced Raman spectroscopy [3] allow for high-sensitivity and on-time analysis, making it possible to analyze even low-affinity interactions. Regarding the synthesis of oligosaccharides, which was described as a challenge in 2018, there have been more examples of solid-phase synthesis [4], but automatic synthesizers are still under development.