At the end of 2019, a series of unknown cases of pneumonia were reported worldwide [1]. Through sequencing the samples from pneumonia patients, it was determined that the severe acute respiratory syndrome is caused by a novel coronavirus (SARS-CoV-2). Later, this unknown pneumonia was named COVID-19 by World Health Organization (WHO) in January 2020. Considering its rapid spread, the WHO classified COVID-19 as the pandemic level on March 12, 2020. The outbreak of COVID-19 presented a significant challenge to the security of global public health and severely impeded global economic growth. Furthermore, the asymptomatic/presymptomatic infected person that could also carry and spread SARS-CoV-2 [2, 3] makes timely and effective screening and isolation difficult, exacerbating the escalation of the pandemic. The control strategies based on vaccine-induced preimmunization and pharmacological treatment have demonstrated limited efficacy. So, screening and isolating the infected samples by developing rapid and specific detection methods is meaningful for blocking the source of the epidemic and effectively preventing the spreading of SARS-CoV-2.

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Nucleic Acid Analysis-Based Methods for SARS-CoV-2 Detection

  • Yang Sun,
  • Weixiang Hong

摘要

At the end of 2019, a series of unknown cases of pneumonia were reported worldwide [1]. Through sequencing the samples from pneumonia patients, it was determined that the severe acute respiratory syndrome is caused by a novel coronavirus (SARS-CoV-2). Later, this unknown pneumonia was named COVID-19 by World Health Organization (WHO) in January 2020. Considering its rapid spread, the WHO classified COVID-19 as the pandemic level on March 12, 2020. The outbreak of COVID-19 presented a significant challenge to the security of global public health and severely impeded global economic growth. Furthermore, the asymptomatic/presymptomatic infected person that could also carry and spread SARS-CoV-2 [2, 3] makes timely and effective screening and isolation difficult, exacerbating the escalation of the pandemic. The control strategies based on vaccine-induced preimmunization and pharmacological treatment have demonstrated limited efficacy. So, screening and isolating the infected samples by developing rapid and specific detection methods is meaningful for blocking the source of the epidemic and effectively preventing the spreading of SARS-CoV-2.