Organic molecules containing a sulfur atom bonded to two carbon atoms, one of which is typically a stereogenic center, represent a versatile and important class of compounds in organic synthesis, medicinal chemistry, and materials science. Their asymmetric architecture, especially when centered around sulfur or adjacent chiral carbon atoms, lends them [38]. These molecules are frequently encountered in biologically active natural products, pharmaceuticals, agrochemicals, and functional materials [39, 40]. In particular, their ability to coordinate with metals, influence reactivity through stereo-electronic effects, and participate in redox processes underlines their value as ligands, catalysts, and intermediates [41]. Consequently, developing reliable, efficient, and enantioselective synthetic strategies for chiral thioethers remains a key objective in modern synthetic chemistry. Novel approaches to achieve the asymmetric synthesis of chiral thioethers offer significant contributions to the synthesis of pharmaceuticals containing thioether moieties [16, 42].

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Synthesis of Chiral Thioethers

  • Qingle Zeng,
  • Muhammad Khuzaifa

摘要

Organic molecules containing a sulfur atom bonded to two carbon atoms, one of which is typically a stereogenic center, represent a versatile and important class of compounds in organic synthesis, medicinal chemistry, and materials science. Their asymmetric architecture, especially when centered around sulfur or adjacent chiral carbon atoms, lends them [38]. These molecules are frequently encountered in biologically active natural products, pharmaceuticals, agrochemicals, and functional materials [39, 40]. In particular, their ability to coordinate with metals, influence reactivity through stereo-electronic effects, and participate in redox processes underlines their value as ligands, catalysts, and intermediates [41]. Consequently, developing reliable, efficient, and enantioselective synthetic strategies for chiral thioethers remains a key objective in modern synthetic chemistry. Novel approaches to achieve the asymmetric synthesis of chiral thioethers offer significant contributions to the synthesis of pharmaceuticals containing thioether moieties [16, 42].