The advantages of using screw extrusion in the production of energetic materials are efficient and continuous production, precise process control, and uniform mixing of materials. In order to study the internal flow field state and safety performance of energetic materials during screw forming, a dynamic model of the screw compression molding process was established, which took into account the non-Newtonian fluid characteristics of the material and the non-isothermal flow of the material during the molding process. Polyflow software was used to numerically simulate the molding process under different process parameters. The influence of screw speed, process temperature, slip conditions, etc. on the safety of screw molding was analyzed by studying the distribution of material pressure field, temperature field and viscosity field. The results show that the material pressure near the screw ridge is greater than that at the screw groove; as the screw speed increases, the material temperature and pressure increase, and the viscosity decreases; the material temperature increases with the increase of process temperature, while the pressure and viscosity decrease. As the slip degree increases, the shear rate decreases, the shear stress increases, and the pressure increases. The research results of this paper provide a theoretical basis for selecting appropriate screw speed and process temperature for screw compression molding process, which is beneficial to improve product quality and reduce the risk of safety accidents.