In718 nickel-based superalloy has become a critical material for key aero-engine components such as turbine disks and blades. With the advancement of additive manufacturing technologies, In718 alloy produced by these methods demonstrates promising application prospects due to its cost-effectiveness, process simplicity, and capability to form intricate components. Among various additive manufacturing techniques, laser metal deposition (LMD) stands out prominently. Nevertheless, LMD-manufactured In718 alloy exhibits inherent defects, including porosity and detrimental Laves phases, which may compromise its wear resistance. During aero-engine operation, turbine disks and blades connected via tenon-mortise joints undergo cyclic relative motions under continuous aerodynamic and centrifugal forces, resulting in prolonged fretting wear at contact interfaces. This phenomenon may initiate surface crack nucleation and propagation, thereby affecting engine performance and operational safety. To investigate the fretting wear characteristics of LMD-manufactured In718 alloy, this study conducts preliminary microstructural analysis of the additively manufactured alloy, predicts its wear resistance, and designs a dedicated fretting wear test apparatus to systematically perform wear tests under varying operating conditions. This study aims to predict the fretting wear performance of LMD-manufactured In718 alloy through comprehensive microstructural characterization and conduct comparative experimental analysis of the influence of different operating conditions on fretting wear characteristics of specimens, providing valuable practical guidance for the application of LMD-manufactured In718 alloy in aero-engine systems.