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This paper introduces a higher-order adaptive network model to analyze the epigenetic influence in the development and persistence of NREM and REM Parasomnias. The model analyzes epigenetic mechanisms in parasomnia pathogenesis, focusing on dysregulation in neuroplasticity (BDNF), circadian regulation (PER2), and stress-response (FOS) genes that disrupt: (1) REM atonia through impaired GABAergic signaling, and (2) NREM stability via thalamocortical hyperexcitability.

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Modeling Epigenetics for Stress-Induced Parasomnias Through Multi-Order Adaptive Self-Modelling Networks

  • 会议论文

  • 发表日期：

    2026年

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  • Jaïr Telting,
  • Sophie C. F. Hendrikse,
  • Jan Treur

摘要

This paper introduces a higher-order adaptive network model to analyze the epigenetic influence in the development and persistence of NREM and REM Parasomnias. The model analyzes epigenetic mechanisms in parasomnia pathogenesis, focusing on dysregulation in neuroplasticity (BDNF), circadian regulation (PER2), and stress-response (FOS) genes that disrupt: (1) REM atonia through impaired GABAergic signaling, and (2) NREM stability via thalamocortical hyperexcitability.