Pyrroloquinoline quinone (PQQ) is a coenzyme present in small amounts in food and human tissues and is known for its antioxidant, antiaging, and metabolic benefits. Its daily intake (20 mg) supports functions, such as memory, attention, and cognitive flexibility. PQQ also aids in obesity management by boosting mitochondrial function, increasing fat oxidation, and reducing fat accumulation and inflammation. It activates AMPK signaling and promotes mitochondrial biogenesis while suppressing lipid synthesis. Animal studies have highlighted its ability to reduce body fat, maintain muscle mass, and improve metabolic health. These multifunctional properties make PQQ a promising ingredient for functional foods.